Preoperative short-course radiotherapy in rectal cancer patients: results and prognostic factors

Preoperative short-course radiotherapy in rectal cancer patients: results and prognostic factors

Objective The purpose of this study was to evaluate the clinical outcome of preoperative short-course radiotherapy for rectal cancer patients. Methods The study group comprised 210 patients with pathologically proven resectable rectal cancer. Between 2001 and 2013, they were treated preoperatively with short-course radiotherapy (25 Gy delivered in five fractions), followed by total mesorectal...

Clinical results and toxicity for short-course preoperative radiotherapy and total mesorectal excision in rectal cancer patients

Short-course preoperative radiotherapy (SCPRT) is an alternative method to chemoirradiation for patients with Stage II and III rectal cancer when no downsizing is needed, but there is still widespread reluctance to use this method because of fear of side effects from high-fraction doses. This paper reports on a single institution patient cohort of operated rectal cancer patients after SCPRT, ev...

Long-term results of a randomized trial comparing preoperative short-course radiotherapy with preoperative conventionally fractionated chemoradiation for rectal cancer.

BACKGROUND Neoadjuvant chemoradiotherapy does not alter anal sphincter preservation or postoperative complications compared with short-course radiotherapy alone in patients with clinical stage T3 or T4 resectable rectal cancer. The aim of this study was to compare survival, local control and late toxicity in the two treatment groups. METHODS The study randomized 312 patients to receive either...

Preoperative radiotherapy "short course" in rectal cancer in elder patient: low impact on tumor regression

morbidity and mortality following short course preoperative radiotherapy in rectal carcinoma

the aim of this study was to evaluate the morbidity and mortality in patients with operable stage ii and iii rectal cancers within one or two months after surgery, who has been treated pre-operatively with short course radiotherapy. twenty-eight patients with rectal adenocarcinoma, consecutively referred to the cancer institute of imam khomeini hospital from march 2009 to march 2010, were selec...